Parts Used & Where Grown
Sage is a silvery-green shrub with very fragrant leaves. The most commonly cultivated species of sage originally came from the area around the Mediterranean but now also grows in North America. The leaves of this common kitchen herb are used in medicine as well as in cooking.1
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Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
3 Stars Reliable and relatively consistent scientific data showing a substantial health benefit.
2 Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1 Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
This supplement has been used in connection with the following health conditions:
Traditional Use (May Not Be Supported by Scientific Studies)
Sage has one of the longest histories of use of any culinary or medicinal herb. It was used by herbalists externally to treat sprains, swelling, ulcers, and bleeding.2 Internally, a tea made from sage leaves has had a long history of use to treat sore throats and coughs —often used as a gargle. It was also used by herbalists for rheumatism, excessive menstrual bleeding, and to dry up a mother’s milk when nursing was stopped. It was particularly noted for strengthening the nervous system, improving memory, and sharpening the senses.3 Sage was officially listed in the United States Pharmacopoeia from 1840 to 1900.
How It Works
How It Works
The volatile oil of sage contains the constituents alpha- and beta-thujone, camphor, and cineole.24 It also contains rosmarinic acid, tannins, and flavonoids. In modern European herbal medicine, a gargle of sage tea is commonly recommended to treat sore throat , inflammations in the mouth, and gingivitis (inflammation of the gums).25 Test tube studies have found that sage oil has antibacterial, antifungal, and antiviral activity which may partially explain the effectiveness of sage for these indications.26
Sage is also approved in Germany for mild gastrointestinal upset and excessive sweating.27 An unpublished, preliminary German study with people suffering from excessive perspiration found that either a dry leaf extract or an infusion of the leaf reduced sweating by as much as 50%.28 A report from the United Kingdom indicates that herbalists there employ sage to treat symptoms of menopause such as hot flashes.29
How to Use It
For treatment of sore throats , inflammation in the mouth, or gingivitis , 3 grams of the chopped leaf can be added to 150 ml of boiling water and strained after 10 minutes.30 This is then used as a mouthwash or gargle several times daily. Alternatively, one may use 5 ml of fluid extract (1:1) diluted in one glass of water, several times daily. For internal use, the same tea preparation described above may be taken three times per day.
Interactions with Supplements, Foods, & Other Compounds
At the time of writing, there were no well-known supplement or food interactions with this supplement.
Interactions with Medicines
As of the last update, no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.
Concern has been expressed about the internal use of sage due to the presence of thujone.31 Even when consumed in small amounts for long periods of time, thujone may cause increased heart rate and mental confusion. Very high amounts (several times greater than one receives if taking sage as instructed above), may lead to convulsions. If one takes sage internally, it is best to limit use to the recommended amounts and to periods of no more than one to two weeks. Extracts of sage made with alcohol are likely to be higher in thujone than those made with water. Sage oil should never be consumed without being first diluted in water. Sage should not be used internally during pregnancy . These concerns do not extend to the use of sage as a gargle or mouth rinse. Sage should be avoided when fever is present.
1. Blumenthal M, Goldberg A, Brinkman J (eds). Herbal Medicine: The Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications, 2000, 330–4.
2. Foster S. 101 Medicinal Herbs. Loveland, CO: Interweave Press, 1998, 176–7.
3. Foster S, Tyler VE. Tyler’s Honest Herbal. New York: Haworth Press, 1999, 327–9.
4. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial. J Clin Pharm Ther 2003;28:53–9.
5. Serfaty R, Itic J. Comparative trial with natural herbal mouthwash versus chlorhexidine in gingivitis. J Clin Dentistry 1988;1:A34.
6. Yamnkell S, Emling RC. Two-month evaluation of Parodontax dentifrice. J Clin Dentistry 1988;1:A41.
7. Forster HB, Niklas H, Lutz S. Antispasmodic effects of some medicinal plants. Planta Med 1980;40:303–19.
8. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998, 425–6.
9. Weiss RF. Herbal Medicine. Beaconsfield, UK: Beaconsfield Publishers Ltd, 1988, 185–6.
10. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998, 198.
11. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 420–1 [review].
12. De Leo V, Lanzetta D, Cazzavacca R, Morgante G. [Treatment of neurovegetative menopausal symptoms with a phytotherapeutic agent] [Article in Italian] Minerva Ginecol 1998;50:207–11.
13. Schilcher H. Phytotherapy in Paediatrics. Stuttgart, Germany: Medpharm Scientific Publishers, 1997, 126–7.
14. Kato T, Iijima H, Ishihara K, et al. Antibacterial effects of Listerine on oral bacteria. Bull Tokyo Dent Coll 1990;31:301–7.
15. Cosentino S, Tuberoso CI, Pisano B, et al. In-vitro antimicrobial activity and chemical composition of Sardinian Thymus essential oils. Lett Appl Microbiol 1999;29:130–5.
16. Petersson LG, Edwardsson S, Arends J. Antimicrobial effect of a dental varnish, in vitro. Swed Dent J 1992;16:183–9.
17. Cox SD, Mann CM, Markham JL, et al. The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil). J Appl Microbiol 2000;88:170–5.
18. Serfaty R, Itic J. Comparative trial with natural herbal mouthwash versus chlorhexidine in gingivitis. J Clin Dent 1988;1:A34–7.
19. Dolara P, Corte B, Ghelardini C, et al. Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh. Planta Med 2000;66:356–8.
20. Hannah JJ, Johnson JD, Kuftinec MM. Long-term clinical evaluation of toothpaste and oral rinse containing sanguinaria extract in controlling plaque, gingival inflammation, and sulcular bleeding during orthodontic treatment. Am J Orthod Dentofacial Orthop 1989;96:199–207.
21. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 420–1 [review].
22. De Leo V, Lanzetta D, Cazzavacca R, Morgante G. [Treatment of neurovegetative menopausal symptoms with a phytotherapeutic agent] [Article in Italian] Minerva Ginecol 1998;50:207–11.
23. Weiss RF. Herbal Medicine. Gothenburg, Sweden: Ab Arcanum and Beaconsfield, UK: Beaconsfield Publishers Ltd., 1988, 229–30.
24. Wichtl M. Herbal Drugs and Phytopharmaceuticals. Boca Raton, FL: CRC Press, 1994, 440–3.
25. ESCOP 1996. Salviae folium (Sage leaf). Monographs on the Medicinal Use of Plant Drugs. Exeter, UK: European Scientific Cooperative on Phytotherapy, 1997.
26. ESCOP 1996. Salviae folium (Sage leaf). Monographs on the Medicinal Use of Plant Drugs. Exeter, UK: European Scientific Cooperative on Phytotherapy, 1997.
27. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council and Boston: Integrative Medicine Communications, 1998, 198.
28. ESCOP 1996. Salviae folium (Sage leaf). Monographs on the Medicinal Use of Plant Drugs. Exeter, UK: European Scientific Cooperative on Phytotherapy, 1997.
29. Beatty C, Denham A. Review of practice: Preliminary data collection for clinical audit. Eur J Herbal Med 1998;4:32–4.
30. Wichtl M. Herbal Drugs and Phytopharmaceuticals. Boca Raton, FL: CRC Press, 1994, 440–3.
31. Foster S, Tyler VE. Tyler’s Honest Herbal. New York: Haworth Press, 1999, 327–9.
Last Review: 11-07-2012
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2013.
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