Diethylstilbestrol (DES) is a medication prescribed in the United
States between 1948 and 1971 to prevent miscarriage or premature delivery. It
is no longer prescribed because it was found to cause various medical problems
in the children of the women who used it.
Daughters born to women who took DES while pregnant have a slightly
higher risk of developing:
Abnormal cervical cells that cause an abnormal
Cancer of the cervix or vagina.
problems in their reproductive organs, such as a T-shaped uterus or a weakened
cervix, which can cause infertility and a higher risk of preterm labor.
Sons born to women who took DES while pregnant have a slightly
higher risk of abnormalities of the scrotum and decreased sperm counts.
Sarah Marshall, MD - Family Medicine & William Gilbert, MD - Maternal and Fetal Medicine
How this information was developed to help you make better health decisions.